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CFTR Inhibitors for Treating Diarrheal Disease

Secretory diarrhea remains a major health challenge worldwide. Excessive fluid secretion in the intestine caused by enterotoxins results in activation of luminal Cl(−) channels on enterocytes. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is the major cyclic adenosine monoph...

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Bibliografiske detaljer
Main Authors: Thiagarajah, JR, Verkman, AS
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643514/
https://ncbi.nlm.nih.gov/pubmed/22850599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2012.114
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