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Mutant SOD1 microglia-generated nitroxidative stress promotes toxicity to human fetal neural stem cell-derived motor neurons through direct damage and noxious interactions with astrocytes

Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. Human neural stem cells (hNSCs) may have the potential to replace lost motor neurons. The therapeutic efficacy of stem cell therapy depends greatly on the survival of grafted stem cell-derived motor neurons in the microenviro...

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Sonraí Bibleagrafaíochta
Main Authors: Thonhoff, Jason R, Gao, Junling, Dunn, Tiffany J, Ojeda, Luis, Wu, Ping
Formáid: Artigo
Teanga:Inglês
Foilsithe: e-Century Publishing Corporation 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643388/
https://ncbi.nlm.nih.gov/pubmed/23671793
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