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Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression
p53 is a major tumor suppressor whose function is pivotal for protection against cancer. In over half of human cancers, p53 is inactivated due to either point mutation or loss of p53 gene. It has been well established that in addition to abrogating the tumor-suppressive function of wild-type p53, mu...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642368/ https://ncbi.nlm.nih.gov/pubmed/23559009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.97 |
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