Substrate Specificity of MarP, a Periplasmic Protease Required for Resistance to Acid and Oxidative Stress in Mycobacterium tuberculosis

The transmembrane serine protease MarP is important for pH homeostasis in Mycobacterium tuberculosis (Mtb). Previous structural studies revealed that MarP contains a chymotrypsin fold and a disulfide bond that stabilizes the protease active site in the substrate-bound conformation. Here, we determin...

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Autors principals: Small, Jennifer L., O'Donoghue, Anthony J., Boritsch, Eva C., Tsodikov, Oleg V., Knudsen, Giselle M., Vandal, Omar, Craik, Charles S., Ehrt, Sabine
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642297/
https://ncbi.nlm.nih.gov/pubmed/23504313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.456541
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