Substrate Specificity of MarP, a Periplasmic Protease Required for Resistance to Acid and Oxidative Stress in Mycobacterium tuberculosis

The transmembrane serine protease MarP is important for pH homeostasis in Mycobacterium tuberculosis (Mtb). Previous structural studies revealed that MarP contains a chymotrypsin fold and a disulfide bond that stabilizes the protease active site in the substrate-bound conformation. Here, we determin...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Small, Jennifer L., O'Donoghue, Anthony J., Boritsch, Eva C., Tsodikov, Oleg V., Knudsen, Giselle M., Vandal, Omar, Craik, Charles S., Ehrt, Sabine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642297/
https://ncbi.nlm.nih.gov/pubmed/23504313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.456541
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi