IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought tha...

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Detalhes bibliográficos
Main Authors: Fink, Karin, Martin, Lydie, Mukawera, Esperance, Chartier, Stéfany, De Deken, Xavier, Brochiero, Emmanuelle, Miot, Françoise, Grandvaux, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641604/
https://ncbi.nlm.nih.gov/pubmed/23545780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.47
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