E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation

CCAAT/enhancer-binding protein alpha (C/EBPα) is an important transcription factor involved in granulocytic differentiation. Here, for the first time we demonstrate that E6-associated protein (E6AP), an E3 ubiquitin ligase targets C/EBPα for ubiquitin-mediated proteasome degradation and thereby nega...

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Detalhes bibliográficos
Main Authors: Pal, P, Lochab, S, Kanaujiya, J K, Kapoor, I, Sanyal, S, Behre, G, Trivedi, A K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641343/
https://ncbi.nlm.nih.gov/pubmed/23598402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.120
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