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An Unusual Conformation of MSH Analogues Leads to a Selective Human Melanocortin 1 Receptor Antagonist for Targeting Melanoma Cells

γ-MSH (γ-melanocyte-stimulating hormone: H-Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-Gly-OH), with its exquisite specificity and potency, has recently created much excitement as a drug lead. However, this peptide like most peptides susceptible to proteolysis in vivo which potentially decreases its...

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Bibliografske podrobnosti
Main Authors: Cai, Minying, Stankova, Magda, Muthu, Dhanasekaran, Mayorov, Alexander, Yang, Zhehui, Trivedi, Devendra, Cabello, Christopher, Hruby, Victor J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641192/
https://ncbi.nlm.nih.gov/pubmed/23276279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300723f
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