Cyclic Lactam Hybrid α-MSH/Agouti-Related Protein (AGRP) Analogues with Nanomolar Range Binding Affinities at the Human Melanocortin Receptors

A novel hybrid melanocortin pharmacophore was designed based on the topographical similarities between the pharmacophores of Agouti related protein (AGRP) an endogenous melanocortin antagonist, and α-melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin agonist. When employed in two dif...

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Detalhes bibliográficos
Main Authors: Mayorov, Alexander V., Cai, Minying, Palmer, Erin S., Tanaka, Dustin K., Cain, James P., Dedek, Matthew M., Tan, Bahar, Trivedi, Dev, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216836/
https://ncbi.nlm.nih.gov/pubmed/21486697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.03.019
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