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The on/off switches of the mitochondrial uncoupling proteins
Mitochondrial uncoupling proteins disengage substrate oxidation from ADP phosphorylation by dissipating the proton electrochemical gradient that is required for ATP synthesis. In doing this, the archetypal uncoupling protein, UCP1, mediates adaptive thermogenesis. By contrast, its paralogues UCP2 an...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640847/ https://ncbi.nlm.nih.gov/pubmed/20006514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2009.11.001 |
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