Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-Wide Profiling of Inflammatory Cistromes

How the glucocorticoid receptor (GR) activates some genes while potently repressing others remains an open question. There are three current models for suppression: trans-repression via GR ‘tethering’ to AP-1/NF-κB sites, direct GR association with inhibitory elements (nGREs), and GR recruitment of...

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Главные авторы: Uhlenhaut, N. Henriette, Barish, Grant D., Yu, Ruth T., Downes, Michael, Karunasiri, Malith, Liddle, Christopher, Schwalie, Petra, Hübner, Norbert, Evans, Ronald M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640846/
https://ncbi.nlm.nih.gov/pubmed/23159735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.013
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