The Bcl6–SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis

Chronic inflammation is a hallmark of atherosclerosis, but its transcriptional underpinnings are poorly understood. We show that the transcriptional repressor Bcl6 is an anti-inflammatory regulator whose loss in bone marrow of Ldlr(−/−) mice results in severe atherosclerosis and xanthomatous tendoni...

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Main Authors: Barish, Grant D., Yu, Ruth T., Karunasiri, Malith S., Becerra, Diana, Kim, Jason, Tseng, Tiffany W., Tai, Li-Jung, LeBlanc, Matthias, Diehl, Cody, Cerchietti, Leandro, Miller, Yury I., Witztum, Joseph L., Melnick, Ari M., Dent, Alexander L., Tangirala, Rajendra K., Evans, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367511/
https://ncbi.nlm.nih.gov/pubmed/22465074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.02.012
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