A Rapid Non Invasive L-DOPA-(13)C Breath Test for Optimally Suppressing Extracerebral AADC Enzyme Activity - Toward Individualizing Carbidopa Therapy in Parkinson’s Disease

BACKGROUND: Peripheral carbidopa (CD) levels directly impact on central dopamine (DA) production in Parkinson disease (PD) through extracerebral inhibition of dopa decarboxylase (AADC) resulting in an increase in levodopa (LD) bioavailability. OBJECTIVE: Recent data suggests that higher CD doses tha...

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Bibliographic Details
Main Authors: Modak, Anil, Durso, Raymon, Josephs, Ephraim, Rosen, David
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640795/
https://ncbi.nlm.nih.gov/pubmed/23646099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-012132
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