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Mutations in interaction surfaces differentially impact E. coli Hfq association with small RNAs and their mRNA targets

The RNA chaperone protein Hfq is required for the function of all small RNAs (sRNAs) that regulate mRNA stability or translation by limited base pairing in E. coli. While there have been numerous in vitro studies to characterize Hfq activity and the importance of specific residues, there has been on...

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Bibliografske podrobnosti
Main Authors: Zhang, Aixia, Schu, Daniel J., Tjaden, Brian C., Storz, Gisela, Gottesman, Susan
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640674/
https://ncbi.nlm.nih.gov/pubmed/23318956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.01.006
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