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Regulation of Telomerase Alternative Splicing: A New Target for Chemotherapy
Telomerase is present in human cancer cells but absent in most somatic tissues. The mRNA of human telomerase (hTERT) is alternatively spliced into mostly non-functional products. We sought to understand splicing so we could decrease functional splice isoforms to reduce telomerase activity to complem...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3640656/ https://ncbi.nlm.nih.gov/pubmed/23562158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.011 |
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