An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase ac...

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Détails bibliographiques
Auteurs principaux: Yi, Xiaoming, White, Dennis M, Aisner, Dara L, Baur, Joseph A, Wright, Woodring E, Shay, Jerry W
Format: Artigo
Langue:Inglês
Publié: Nature America, Inc. 2000
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507981/
https://ncbi.nlm.nih.gov/pubmed/11191110
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