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Regulation of Telomerase Alternative Splicing: A New Target for Chemotherapy

Telomerase is present in human cancer cells but absent in most somatic tissues. The mRNA of human telomerase (hTERT) is alternatively spliced into mostly non-functional products. We sought to understand splicing so we could decrease functional splice isoforms to reduce telomerase activity to complem...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wong, Mandy S., Chen, Ling, Foster, Christopher, Kainthla, Radhika, Shay, Jerry W., Wright, Woodring E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640656/
https://ncbi.nlm.nih.gov/pubmed/23562158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.011
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