Shiga Toxin 1, as DNA Repair Inhibitor, Synergistically Potentiates the Activity of the Anticancer Drug, Mafosfamide, on Raji Cells

Shiga toxin 1 (Stx1), produced by pathogenic Escherichia coli, targets a restricted subset of human cells, which possess the receptor globotriaosylceramide (Gb3Cer/CD77), causing hemolytic uremic syndrome. In spite of the high toxicity, Stx1 has been proposed in the treatment of Gb3Cer/CD77-expressi...

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Autors principals: Brigotti, Maurizio, Arfilli, Valentina, Carnicelli, Domenica, Rocchi, Laura, Calcabrini, Cinzia, Ricci, Francesca, Pagliaro, Pasqualepaolo, Tazzari, Pier Luigi, Alfieri, Roberta R., Petronini, Pier Giorgio, Sestili, Piero
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640543/
https://ncbi.nlm.nih.gov/pubmed/23430607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins5020431
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