Molecular Damage and Induction of Proinflammatory Cytokines in Human Endothelial Cells Exposed to Shiga Toxin 1, Shiga Toxin 2, and α-Sarcin

Treatment of human endothelial cells with Shiga toxin 1 and 2 leads to the upregulation of genes encoding proinflammatory molecules involved in the pathogenesis of hemolytic-uremic syndrome. The paradoxical effect of inhibitors of mRNA translation, such as Shiga toxins, that at the same time induce...

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Bibliografiske detaljer
Main Authors: Brigotti, Maurizio, Carnicelli, Domenica, Ravanelli, Elisa, Vara, Antonio González, Martinelli, Chiara, Alfieri, Roberta R., Petronini, Pier Giorgio, Sestili, Piero
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865781/
https://ncbi.nlm.nih.gov/pubmed/17296757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01707-06
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