Change in Conformation with Reduction of α-Helix Content Causes Loss of Neutrophil Binding Activity in Fully Cytotoxic Shiga Toxin 1

Shiga toxins (Stx) play an important role in the pathogenesis of hemolytic uremic syndrome, a life-threatening renal sequela of human intestinal infection caused by specific Escherichia coli strains. Stx target a restricted subset of human endothelial cells that possess the globotriaosylceramide rec...

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Bibliographic Details
Main Authors: Brigotti, Maurizio, Carnicelli, Domenica, Arfilli, Valentina, Rocchi, Laura, Ricci, Francesca, Pagliaro, Pasqualepaolo, Tazzari, Pier Luigi, Vara, Antonio González, Amelia, Matteo, Manoli, Francesco, Monti, Sandra
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186412/
https://ncbi.nlm.nih.gov/pubmed/21832076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255414
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