CASK Functions as a Mg2+-independent neurexin kinase

CASK is a unique MAGUK protein that contains an N-terminal CaM-kinase domain besides the typical MAGUK domains. The CASK CaM-kinase domain is presumed to be a catalytically inactive pseudokinase because it lacks the canonical DFG-motif required for Mg(2+)-binding. Here we show, however, that CASK fu...

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Huvudupphovsmän: Mukherjee, Konark, Sharma, Manu, Urlaub, Henning, Bourenkov, Gleb P., Jahn, Reinhard, Südhof, Thomas C., Wahl, Markus C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640377/
https://ncbi.nlm.nih.gov/pubmed/18423203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.02.036
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