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Evolution of CASK into a Mg(2+)-sensitive kinase
All known protein kinases, except CASK, require Mg(2+) to stimulate phosphotransfer from ATP to a protein substrate. The CaM-kinase domain of CASK exhibits activity in the absence of Mg(2+), moreover it is inhibited by divalent ions including Mg(2+). Here, we converted the Mg(2+)-inhibited wild type...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286871/ https://ncbi.nlm.nih.gov/pubmed/20424264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000800 |
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