Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients

BACKGROUND: Tacrolimus is one of the commonly used immunosuppressive drugs for pediatric heart transplants. Large variation exists in pharmacokinetics during the direct post-transplant period, resulting in an increased risk of adverse events. Limited data are available on the interaction of age, CYP...

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Main Authors: Gijsen, Violette, Mital, Seema, Van Schaik, Ron H., Soldin, Offie P., Soldin, Steven J., van der Heiden, Ilse P., Nulman, Irena, Koren, Gideon, de Wildt, Saskia N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640375/
https://ncbi.nlm.nih.gov/pubmed/21930396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.healun.2011.08.001
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