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Structure-Based Design and Synthesis of Benzothiazole Phosphonate Analogues with Inhibitors of Human ABAD-Aβ for Treatment of Alzheimer’s disease

Amyloid binding alcohol dehydrogenase (ABAD), a mitochondrial protein, is a cofactor facilitating amyloid-β peptide (Aβ) induced cell stress. Antagonizing Aβ-ABAD interaction protects against aberrant mitochondrial and neuronal function and improves learning memory in the Alzheimer’s disease (AD) mo...

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Autori principali: Valasani, Koteswara Rao, Hu, Gang, Chaney, Michael O., Yan, Shirley ShiDu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640359/
https://ncbi.nlm.nih.gov/pubmed/23039767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12068
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