A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supp...

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主要な著者: Newgard, Christopher B, An, Jie, Bain, James R, Muehlbauer, Michael J, Stevens, Robert D, Lien, Lillian F, Haqq, Andrea M, Shah, Svati H., Arlotto, Michelle, Slentz, Cris A, Rochon, James, Gallup, Dianne, Ilkayeva, Olga, Wenner, Brett R, Yancy, William E, Eisenson, Howard, Musante, Gerald, Surwit, Richard, Millington, David S, Butler, Mark D, Svetkey, Laura P
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640280/
https://ncbi.nlm.nih.gov/pubmed/19356713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.02.002
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