A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supp...

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Autors principals: Newgard, Christopher B, An, Jie, Bain, James R, Muehlbauer, Michael J, Stevens, Robert D, Lien, Lillian F, Haqq, Andrea M, Shah, Svati H., Arlotto, Michelle, Slentz, Cris A, Rochon, James, Gallup, Dianne, Ilkayeva, Olga, Wenner, Brett R, Yancy, William E, Eisenson, Howard, Musante, Gerald, Surwit, Richard, Millington, David S, Butler, Mark D, Svetkey, Laura P
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640280/
https://ncbi.nlm.nih.gov/pubmed/19356713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.02.002
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