A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supp...

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Hlavní autoři: Newgard, Christopher B, An, Jie, Bain, James R, Muehlbauer, Michael J, Stevens, Robert D, Lien, Lillian F, Haqq, Andrea M, Shah, Svati H., Arlotto, Michelle, Slentz, Cris A, Rochon, James, Gallup, Dianne, Ilkayeva, Olga, Wenner, Brett R, Yancy, William E, Eisenson, Howard, Musante, Gerald, Surwit, Richard, Millington, David S, Butler, Mark D, Svetkey, Laura P
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640280/
https://ncbi.nlm.nih.gov/pubmed/19356713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.02.002
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