A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supp...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Newgard, Christopher B, An, Jie, Bain, James R, Muehlbauer, Michael J, Stevens, Robert D, Lien, Lillian F, Haqq, Andrea M, Shah, Svati H., Arlotto, Michelle, Slentz, Cris A, Rochon, James, Gallup, Dianne, Ilkayeva, Olga, Wenner, Brett R, Yancy, William E, Eisenson, Howard, Musante, Gerald, Surwit, Richard, Millington, David S, Butler, Mark D, Svetkey, Laura P
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640280/
https://ncbi.nlm.nih.gov/pubmed/19356713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.02.002
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