Cetuximab-activated natural killer (NK) and dendritic cells (DC) collaborate to trigger tumor antigen-specific T cell immunity in head and neck cancer patients

PURPOSE: Tumor antigen (TA)-specific monoclonal antibodies (mAb) block oncogenic signaling and induce Fcγ receptor (FcγR)-mediated cytotoxicity. However, the role of CD8(+) cytotoxic T lymphocyte (CTL) and FcγR in initiating innate and adaptive immune responses in mAb-treated human cancer patients i...

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Autors principals: Srivastava, Raghvendra M., Lee, Steve C., Filho, Pedro A. Andrade, Lord, Christopher A., Jie, Hyun-bae, Davidson, H. Carter, López-Albaitero, Andrés, Gibson, Sandra P., Gooding, William E., Ferrone, Soldano, Ferris, Robert L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640274/
https://ncbi.nlm.nih.gov/pubmed/23444227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2426
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