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CTLA-4(+) Regulatory T Cells Increased in Cetuximab Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis
The EGFR-targeted antibody cetuximab is effective against head and neck cancer (HNC), but in only 15 – 20% of patients, and the variability and extent of cetuximab-mediated cellular immunity is not fully understood. We hypothesized that regulatory T cells (Treg) may exert a functional and clinical i...
Shranjeno v:
izdano v: | Cancer Res |
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Main Authors: | , , , , , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2015
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452385/ https://ncbi.nlm.nih.gov/pubmed/25832655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2788 |
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