Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration

Pathologic angiogenesis mediated by abnormally polarized macrophages plays a central role in common age-associated diseases such as atherosclerosis, cancer and macular degeneration. Here we demonstrate that abnormal polarization in older macrophages is caused by programmatic changes that lead to red...

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Hauptverfasser: Sene, Abdoulaye, Khan, Aslam A., Cox, Douglas, Nakamura, Rei E.I., Santeford, Andrea, Kim, Bryan M., Sidhu, Rohini, Onken, Michael D., Harbour, J. William, Haqbi-Levi, Shira, Chowers, Itay, Edwards, Peter A., Baldan, Angel, Parks, John S., Ory, Daniel S, Apte, Rajendra S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640261/
https://ncbi.nlm.nih.gov/pubmed/23562078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.03.009
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