Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets

Thrombin activates platelets mainly through protease-activated receptor (PAR)1 and PAR4. However, downstream platelet signaling between PAR1 and PAR4 is not yet well understood. This study investigated the relationship between nSMase/ceramide and the NF-κB signaling pathway in PARs-mediated human pl...

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Detalhes bibliográficos
Main Authors: Chen, Wei-Fan, Lee, Jie-Jen, Chang, Chao-Chien, Lin, Kuan-Hong, Wang, Shwu-Huey, Sheu, Joen-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640127/
https://ncbi.nlm.nih.gov/pubmed/23065519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.072553
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