IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy

IL-6 plays a central role in supporting pathological T(H2) and T(H17) cell development and inhibiting the protective T regulatory cells in allergic asthma. T(H17) cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced asthma in particular. Here we found an i...

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Main Authors: Koch, Sonja, Mousset, Stephanie, Graser, Anna, Reppert, Sarah, Übel, Caroline, Reinhardt, Cornelia, Zimmermann, Theodor, Rieker, Ralf, Lehr, Hans A., Finotto, Susetta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639449/
https://ncbi.nlm.nih.gov/pubmed/23628948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01754
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