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An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

High-throughput screening (HTS) is a powerful approach to drug discovery, but many lead compounds are found to be unsuitable for use in vivo after initial screening. Screening in small animals like C. elegans can help avoid these problems, but this system has been limited to screens with low-through...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Leung, Chi K., Wang, Ying, Malany, Siobhan, Deonarine, Andrew, Nguyen, Kevin, Vasile, Stefan, Choe, Keith P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639262/
https://ncbi.nlm.nih.gov/pubmed/23637990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062166
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