Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB Signaling Pathway and an NLRP3 Inflammasome Activation

Celiac disease (CD) is a gluten-responsive, chronic inflammatory enteropathy. IL-1 cytokine family members IL-1β and IL-18 have been associated with the inflammatory conditions in CD patients. However, the mechanisms of IL-1 molecule activation in CD have not yet been elucidated. We show in this stu...

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Detalhes bibliográficos
Main Authors: Palová-Jelínková, Lenka, Dáňová, Klára, Drašarová, Hana, Dvořák, Miloš, Funda, David P., Fundová, Petra, Kotrbová-Kozak, Anna, Černá, Marie, Kamanová, Jana, Martin, Stefan F., Freudenberg, Marina, Tučková, Ludmila
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639175/
https://ncbi.nlm.nih.gov/pubmed/23658628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062426
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