A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

Multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, Graves disease, and systemic lupus erythematosus, are associated with an allelic variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22), which encodes the protein LYP. To model the human disease-linked variant LY...

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Main Authors: Dai, Xuezhi, James, Richard G., Habib, Tania, Singh, Swati, Jackson, Shaun, Khim, Socheath, Moon, Randall T., Liggitt, Denny, Wolf-Yadlin, Alejandro, Buckner, Jane H., Rawlings, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638909/
https://ncbi.nlm.nih.gov/pubmed/23619366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66963
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