Altered B cell homeostasis is associated with Type I diabetes and carriers of the PTPN22 allelic variant

The PTPN22 1858T genetic variant (and its gene product Lyp620W) is associated with multiple autoimmune disorders characterized by autoantibody production. Because B cell receptor (BCR) signal strength is tightly coupled to central and peripheral tolerance, and Lyp620W results in blunted B cell recep...

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Bibliographische Detailangaben
Hauptverfasser: Habib, Tania, Funk, Andrew, Rieck, Mary, Brahmandam, Archana, Dai, Xuezhi, Panigrahi, Anil K., Luning Prak, Eline T., Meyer-Bahlburg, Almut, Sanda, Srinath, Greenbaum, Carla, Rawlings, David J., Buckner, Jane H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670766/
https://ncbi.nlm.nih.gov/pubmed/22105996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102176
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