B7-H1 Promotes Germinal Center B cell Survival and Inhibits T cell Activation

The immune system has developed several regulatory mechanisms to maintain homeostasis of adaptive immune responses. T cell PD-1 recognition of B7-H1 (PD-L1) expressed on antigen presenting cells and non-lymphoid tissue regulates T cell activation. We show that B7-H1(−/−) mice exhibit exacerbated pro...

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Bibliographic Details
Main Authors: Hamel, Keith M., Cao, Yanxia, Wang, Yumei, Rodeghero, Rachel, Kobezda, Tamas, Chen, Lieping, Finnegan, Alison
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638795/
https://ncbi.nlm.nih.gov/pubmed/21061440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040690
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