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Sequencing of isolated sperm cells for direct haplotyping of a human genome

There is increasing evidence that the phenotypic effects of genomic sequence variants are best understood in terms of variant haplotypes rather than as isolated polymorphisms. Haplotype analysis is also critically important for uncovering population histories and for the study of evolutionary geneti...

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Détails bibliographiques
Auteurs principaux: Kirkness, Ewen F., Grindberg, Rashel V., Yee-Greenbaum, Joyclyn, Marshall, Christian R., Scherer, Stephen W., Lasken, Roger S., Venter, J. Craig
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638138/
https://ncbi.nlm.nih.gov/pubmed/23282328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.144600.112
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