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Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay
Genome-wide chromatin annotations have permitted the mapping of putative regulatory elements across multiple human cell types. However, their experimental dissection by directed regulatory motif disruption has remained unfeasible at the genome scale. Here, we use a massively parallel reporter assay...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3638136/ https://ncbi.nlm.nih.gov/pubmed/23512712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.144899.112 |
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