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Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions
Massively parallel reporter assays (MPRA) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here, we present a combined experimental and computational approach, Sharpr-MPRA, that allows high-resolution analysis of thousa...
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| Publicado en: | Nat Biotechnol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5125825/ https://ncbi.nlm.nih.gov/pubmed/27701403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3678 |
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