PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice

Exposure to the pesticide paraquat (PQ) increases the risk of Parkinson’s disease (PD), and its effect may be modulated by genetic or other environmental factors. The neuropeptide PACAP (pituitary adenylyl cyclase activating polypeptide, Adcyap1) has been shown to enhance tyrosine hydroxylase (TH) a...

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Main Authors: Watson, Melanie B., Nobuta, Hiroko, Abad, Catalina, Lee, Soo Kyung, Bala, Noor, Zhu, Chunni, Richter, Franziska, Chesselet, Marie-Francoise, Waschek, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637876/
https://ncbi.nlm.nih.gov/pubmed/23500093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.03.002
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