Physiological Brain Activity Causes DNA Double Strand Breaks in Neurons — Exacerbation by Amyloid-β

We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wildtype mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in spatial learning and memory, and were repaired w...

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Main Authors: Suberbielle, Elsa, Sanchez, Pascal E., Kravitz, Alexxai V., Wang, Xin, Ho, Kaitlyn, Eilertson, Kirsten, Devidze, Nino, Kreitzer, Anatol C., Mucke, Lennart
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637871/
https://ncbi.nlm.nih.gov/pubmed/23525040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3356
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