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Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion

Metastasis is the major cause of breast cancer mortality. We recently reported that aberrant G-protein coupled receptor (GPCR) signaling promotes breast cancer metastasis by enhancing cancer cell migration and invasion. Phosphatidylinositol 3-kinase γ (PI3Kγ) is specifically activated by GPCRs. The...

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Bibliografski detalji
Glavni autori: Xie, Yan, Abel, Peter W., Kirui, Joseph K., Deng, Caishu, Sharma, Poonam, Wolff, Dennis W., Toews, Myron L., Tu, Yaping
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637857/
https://ncbi.nlm.nih.gov/pubmed/23500535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.03.001
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