Targeting Phosphoinositide 3-Kinase γ in Airway Smooth Muscle Cells to Suppress Interleukin-13-Induced Mouse Airway Hyperresponsiveness

We recently reported that phosphoinositide 3-kinase γ (PI3Kγ) directly regulates airway smooth muscle (ASM) contraction by modulating Ca(2+) oscillations. Because ASM contraction plays a critical role in airway hyperresponsiveness (AHR) of asthma, the aim of the present study was to determine whethe...

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Detalhes bibliográficos
Main Authors: Jiang, Haihong, Xie, Yan, Abel, Peter W., Toews, Myron L., Townley, Robert G., Casale, Thomas B., Tu, Yaping
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Inflammation, Immunopharmacology, and Asthma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400799/
https://ncbi.nlm.nih.gov/pubmed/22543031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.189704
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