Regulator of G-Protein Signaling 2 Repression Exacerbates Airway Hyper-Responsiveness and Remodeling in Asthma

G protein–coupled receptors (GPCRs) are important regulators of cell functions in asthma. We recently reported that regulator of G-protein signaling (RGS) 2, a selective modulator of G(q)-coupled GPCRs, is a key regulator of airway hyper-responsiveness (AHR), the pathophysiologic hallmark of asthma....

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Jiang, Haihong, Xie, Yan, Abel, Peter W., Wolff, Dennis W., Toews, Myron L., Panettieri, Reynold A., Casale, Thomas B., Tu, Yaping
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566111/
https://ncbi.nlm.nih.gov/pubmed/25368964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0319OC
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