Intercellular trafficking of the nuclear oncoprotein DEK

DEK is a biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity. In addition, DEK can be secreted and function as a chemotactic, proinflammatory factor. Here we show that exogenous DEK can penetrate cells, translocate to the nucleus, and there carry ou...

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Main Authors: Saha, Anjan K., Kappes, Ferdinand, Mundade, Amruta, Deutzmann, Anja, Rosmarin, David M., Legendre, Maureen, Chatain, Nicolas, Al-Obaidi, Zeina, Adams, Barbara S., Ploegh, Hidde L., Ferrando-May, Elisa, Mor-Vaknin, Nirit, Markovitz, David M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637753/
https://ncbi.nlm.nih.gov/pubmed/23569252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220751110
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