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High affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length
Poly(ADP-ribose) polymerase-1 (PARP-1) is a molecular DNA damage sensor that catalyzes the synthesis of the complex biopolymer poly(ADP-ribose) [PAR] under consumption of NAD(+). PAR engages in fundamental cellular processes such as DNA metabolism and transcription, and interacts non-covalently with...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929705/ https://ncbi.nlm.nih.gov/pubmed/20669926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1004365 |
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