Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity

Cell surface heparan sulfate (HS) proteoglycans shape organogenesis and homeostasis by capture and release of morphogens through mechanisms largely thought to exclude the core protein domain. Nevertheless, heparanase deglycanation of the N-terminal HS-rich domain of syndecan-1 (SDC1), but not SDC2 o...

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Hlavní autoři: Zhang, Yinghui, Wang, Ningning, Raab, Ronald W., McKown, Robert L., Irwin, Jacob A., Kwon, Inchan, van Kuppevelt, Toin H., Laurie, Gordon W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636894/
https://ncbi.nlm.nih.gov/pubmed/23504321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422717
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