Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity

Cell surface heparan sulfate (HS) proteoglycans shape organogenesis and homeostasis by capture and release of morphogens through mechanisms largely thought to exclude the core protein domain. Nevertheless, heparanase deglycanation of the N-terminal HS-rich domain of syndecan-1 (SDC1), but not SDC2 o...

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Detalhes bibliográficos
Main Authors: Zhang, Yinghui, Wang, Ningning, Raab, Ronald W., McKown, Robert L., Irwin, Jacob A., Kwon, Inchan, van Kuppevelt, Toin H., Laurie, Gordon W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636894/
https://ncbi.nlm.nih.gov/pubmed/23504321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422717
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