Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity

Lipotoxicity is a presumed pathogenetic process whereby elevated circulating and stored lipids in type 2 diabetes cause pancreatic β-cell failure. To resolve the underlying molecular mechanisms, we exposed clonal INS-1 832/13 β-cells to palmitate for 48 h. We observed elevated basal insulin secretio...

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Autors principals: Malmgren, Siri, Spégel, Peter, Danielsson, Anders P.H., Nagorny, Cecilia L., Andersson, Lotta E., Nitert, Marloes Dekker, Ridderstråle, Martin, Mulder, Hindrik, Ling, Charlotte
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636884/
https://ncbi.nlm.nih.gov/pubmed/23476019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422527
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